For the hell of it, I have made myself a list of my favorite space vehicles from science fiction. To discipline myself I have only allowed myself to pick one ship from each sci-fi source (in other words, I can't pick the Millennium Falcon and Luke's X-Wing Fighter from Star Wars. I have to pick only my favorite ship from that particular Sci-Fi Universe).
#1)USS Enterprise: The one I really dig is the refit Enterprise (NCC 1701) first introduced in Star Trek: the Motion Picture. To me, this one is the classic exploratory/adventure vehicle. I think the ship's best moment was the dog fight with the Reliant in Star Trek II: The Wrath of Khan.
#2) The Discovery: I like this ship from 2001: A Space Odyssey mostly for the fact that it has always seemed so real to me. I also like the fact that HAL, the onboard computer, malfunctions and wipes out most of the crew. It gives the ship a haunted feeling.
#3) The Millennium Falcon: George Lucas is reputed to be a big gear-head, and the Falcon has always struck me as Han Solo's muscle car in space. I love that it was always on the verge of shaking apart at the seams but in a pinch it would pull through.
#4) Serenity: This is the ship that first appared in the Joss Whedon short lived television series, Firefly, and then in the movie, Serenity. It wasn't a battleship. It wasn't an exploratory vessel. It was the home to nine lost souls just trying to survive in a complicated universe.
#5) the TARDIS (Time And Relative Dimensions In Space): The Doctor's seemingly innocuous blue police box (from the long running British television show, Dr. Who) is, in reality, one of the most versatile space vecicles in all of science fiction.
#6) Battlestar Galactica: I like the Galactica from the current series on the Sci-Fi network better than the one from the 1979 show. This old war-horse has tons of personality and really feels like an aircraft carrier in space.
#7) Babylon 5: I know. I know. Technically this is a space station and not a space ship, but it was the location of much intrigue and adventure on the television series of the same name, so it goes on my list.
#8) the Nebuchadnezzar: Morpheus's awesome ship from the Matrix trilogy is really more dedicated to exploring inner-space than outer-space, but that's what gives it it's charm.
#9) the Nostromo: This space mining cargo ship from Alien was dark and creepy and the perfect location for the title creature to creep around in. A true "haunted house" in space.
#10)the Vanguard: This rocket ship from Lance Proton & the Space Battalion of Justice first appeared on the Sterling Radio Showcase. You've got to love a ship that runs on vacuum tubes and sprockets.